北京华睿卓成知识产权代理事务所

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连高焱


博士、副研究员(副教授)、专利代理师

北京华睿卓成知识产权代理事务所(普通合伙)

Tel010-64094682

技术领域

有机化学、药物化学、催化化学、高分子材料、生物化学、生物制药等。


教育背景

1997.9-2001.7  复旦大学化学系学士

2001.9-2007.7  复旦大学化学系沪港联合实验室博士(有机化学专业)

 

职业资格

2014年通过专利代理人资格考试

 

工作经历

2007.8-2015.5   中科院上海有机化学研究所,生命有机国家重点实验室,历任助理研究员(讲师),副研究员(副教授)。

2016.9-2017.9   南京苏高专利商标事务所专利代理师

2017.9-2020.11   南京华讯知识产权顾问有限公司资深专利顾问

 

业务领域

连高焱博士具有一流的教育背景、丰富的医药化学行业研究工作经验和产业经验,以及多年的知识产权从业经历。

作为研究人员,连高焱博士在国际期刊上发表过十余篇高水平的SCI论文,以及多篇综述,并曾作为发明人申请并获得过多项专利,她的研究方向涉及自由基化学、杂环化学、方法学、糖化学以及催化化学,参与众多科研项目且曾担任国家自然科学基金青年基金负责人。

作为生物医药行业资深专利顾问,连高焱博士主要从事化学和药品方向的专利申请、专利挑战、涉外知识产权自由运作权(FTO)分析、尽职调查、布局、导航与运营等各方面的等事务,具有重磅炸弹级药物专利无效挑战成功及转化的经验,参与过科创版企业上市的知识产权辅导工作。她也曾参加台湾智慧财产局知识产权诉讼高级研修班,并曾在德国B&B律师事务所进行为期一周的欧洲知识产权课程学习。她服务的客户包括高校、上市公司和初创企业。


工作语言

中文和英文



发表论文

1.     Thioglycosides in Carbohydrate Research. Gaoyan Lian, Xiaheng Zhang, Biao Yu, Carbohydr. Res. 2015, 403, 13-22.

2.     Naturally Occurring Polyphenolic Glucosidase Inhibitors. You Yang, Gaoyan Lian, Biao Yu, Isr. J. Chem. 2015, 55, 268-284.

3.     A Polystyrene-bound Triphenylphosphine Gold(I) Catalyst for the Glycosylation of Glycosyl ortho-Hexynylbenzoates. Yugen Zhu, Stephane Laval, Yu Tang, Gaoyan Lian, Biao Yu, Asian J. Org. Chem. 2015, 4, 1034-1039.

4.     Revisit of the phenol O-glycosylation with glycosyl imidates, BF3·OEt2 is a better catalyst than TMSOTf. Y. Li, H. Mo, G. Lian, B. Yu, Carbohydr. Res. 2012, 363, 14-22.

5.     蛋白质的化学糖基化研究进展,连高焱、俞飚,中国科学:化学, 2012, 42, 1746-1759.

6.     Identification of 3,6-di-O-acetyl-1,2,4-O-orthoacetyl-a-D-glucopyranose as a direct evidence for the 4-O-acyl group participation in glycosylation. Y. Ma, Gao-yan Lian, Y. Li, B. Yu,* Chem. Commun. 2011, 47, 7515-7517.

7.     Natural Occurring Dimers from Chemical Perspective. (Gao-yan Lian, Biao Yu*) Chemistry & Biodiversity 2010, 7(11), 2660-2691.

8.     Selective Approach toward Multi-functionalized Lactams by Lewis Acid-promoted PhSe-group Transfer Radical Cyclization. (Jin-di Yu, Wei Ding, Gao-Yan Lian; Ke-Sheng Song, Dan-Wei Zhang, Xiang Gao, Dan Yang*). J. Org. Chem., 2010, 75 (10), 3232-3239.

9.     Synthesis of Mangiferin, Isomangiferin, and Homomangiferin. (Zhong-tao Wu, Guo Wei, Gao-yan Lian, Biao Yu) J. Org. Chem., 2010, 75 (16), 5725-5728.

10.  Synthesis of raphanuside, an unusual oxathiane-fused thioglucoside isolated from the seeds of Raphanus sativus L. (Fei Yang, Gao-yan Lian, Biao Yu*) Carbohydr. Res. 2010, 345,309-314.

11.  Synthesis of g-Butyrolactams by Photoinduced PhSe-Group-Transfer Radical Cyclization and Formal Synthesis of (±)-Isocynometrine with Diphenyldiselenide as Promoter. (Dan Yang,* Gao-Yan Lian, Hai-Feng Yang, Jin-Di Yu, Dan-Wei Zhang, and Xiang Gao) J. Org. Chem. 2009, 74, 8610-8615.

12.  The first total synthesis of 7-O-b-D-glucopyranosyl-4’-O-a-L- rhamnopyranosyl apigenin via a hexanoyl ester-based protection strategy. (Qi Gao, Gao-yan Lian, Feng Lin*) Carbohydr. Res. 2009, 344, 511-515.

13.  The efficient total synthesis of bis-glycosyl apigenin from naringenin: a greener way. (Jian-li Chen, Wei Huang, Gao-yan Lian, Feng Lin*) Carbohydr. Res. 2009, 344, 2245-2249.

14.  Synthesis of Fructofuranosides: Efficient Glycosylation with N-Phenyltrifluoro-acetimidate as Leaving Group. (Gao-yan Lian, Qi Gao, Feng Lin. *) Carbohydr. Res. 2008, 343, 2992-2996.

15.  An Efficient Multi-Component Reaction for the Synthesis of Piperidine Derivatives. Yb(OTf)3/AgOTf Co-Catalyzed Preparation of Trimethyl 3,5,5- Piperidonetricarboxylate. (Gao-yan Lian, Feng Lin, Jin-di Yu, and Dan-Wei Zhang*)  Syn. Comm. 2008, 38, 4321-4327.

16.  An Efficient and High Steroselective Method to Synthesize 3-(1-Hydroxyalkyl) Pyrrolidine (Gao-yanLian,*Jin-di Yu, Hai-feng Yang, Feng Lin, Qiang Gao and Dan-Wei Zhang) Chemistry Lett. 2007, 30, 408-409.

17.  A Facile and Efficient Way to Synthesis the Radical Cyclization Percursor: (E)-Methyl 3-(tert-Butyl(3-(2,2-Diphenylcyclopropyl)Allyl)Amino)-3-Oxo-2-(Phenyl selanyl) Propanoate for Kinetic Research. (Jin-di Yu, Gao-yan Lian, Danwei Zhang*) Syn. Comm. 2007, 37, 37-46.

18.  Phenylseleno Group Transfer Cyclization of N-alkenyl a-Phenylselenob-Keto Amides and Formal Synthesis of Key Intermediate of (±)Isocynometrine.Gao-Yan Lian, Hai-Feng Yang, Dan-Wei Zhang and Dan Yang*) YOUJI HUAXUE 2005, 25, Suppl1. 1, 253

19.    The solid-phase synthesis of oligosaccharides. Gao-yan Lian, Biao Yu. ‘10000 Science Challenging Problems’ 2009, 1st ed. P. 301-303, Science Publishing House, Beijing.

20.    The bioactivities mediated through the glycosides’ recognition. Gao-yan Lian, Biao Yu. ‘10000 Science Challenging Problems’ 2009, 1st ed. P. 642-644, Science Publishing House, Beijing.

21.    Translating part of ‘Modern Physical Organic Chemistry’. 2009, 1st ed. High Education Publishing House, Beijing.



申请专利

1.       一种糖胺聚糖类化合物N,O‑同时硫酸化的方法及其反应中间体。俞飚、徐鹏、许伟长、石富春、连高焱、李原强、车大庆、严普查)CN201510023345.3

2.     一种黄酮类化合物的制备方法及所用中间体。 (林峰, 高祺,连高焱陈建丽) CN 200810036839.5

3.     一种黄酮类二聚物的制备方法、及中间体及其制备方法 (林峰高祺连高焱姜浩安泳潼孙云李肇) CN 200810036840.8

4.     黄酮类化合物中间体及其制备方法。(林峰,高祺,连高焱,姜浩,安泳潼,孙云,李肇)CN201210186847.4

5.     黄酮类化合物及其合成方法和应用 (林峰,高祺,连高焱,姜浩,安泳潼,孙云,李肇) CN200910046545.5



业余爱好

在业余时间,连高焱博士喜欢阅读、烹调和烘焙。她是93学社社员(中国民主党派之一)。